KOLAVIRON ANTAGONIZES BIOCHEMICAL ALTERATIONS OCCASIONED BY MERCURY CHLORIDE INTOXICATION IN RAT LIVER HOMOGENATES

A C Akinmoladun

Abstract



Kolaviron is a biflavonoid complex isolated from Garcinia kola seeds which has been reported to possess multiple bioactivities. Mercury is a heavy metal used in industries and found in home appliances but toxic to man on exposure. The liver is the major organ responsible for toxicant metabolism and its health is crucial for overall well-being. In this study, the protective effect of kolaviron on mercury-induced toxicity in rat liver was evaluated. Rat liver homogenate intoxicated with 0.1% HgCl2 was incubated with/without kolaviron and analyzed for biochemical markers of hepatotoxicity. Results showed that kolaviron at concentrations of 100 and 500 µg/ml reversed mercury chloride incited oxidative stress and hepatotoxicity as adjudged by its effects on levels of reduced glutathione and malondialdehyde, and activities of catalase, superoxide dismutase, alanine aminotransferase, aspartate amino transferase and alkaline phosphatase. These results suggest that kolaviron has potential in the management of toxicities and pathologies arising from exposure to mercury.

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