EFFECT OF SYNSEPALUM DULCIFICUM BERRY EXTRACT ON OXIDATIVE STRESS AND HEPATOTOXICITY INDICES, FOLLOWING SUBACUTE ADMINISTRATION IN NORMAL RATS

A C Akinmoladun

Abstract



Toxicological evaluation of Synsepalum dulcificum berry extract was carried out by assessing its effect on oxidative stress and hepatotoxicity markers in rats administered 25-200 mg/kg of the extract for 14 days. Total bilirubrin level was decreased in animals administered the extract compared to untreated ones (P less than 0.05). Extract at 50 mg/kg significantly reduced serum aminotransferase and alkaline phosphatase activities, produced no significant change in aspartate aminotransferase activity but significantly increased catalase activity. Glutathione-S-transferase activity was significantly (P less than 0.05) increased in the 50-200 mg/kg administered groups. Malondialdehyde levels were reduced in groups administered 25-100 mg/kg of extract but significantly increased in the 200 mg/kg group. Glutathione level and activities of catalase and hepatic glutathione peroxidase were reduced in the 200 mg/kg group (P less than 0.05). These results suggest that extract at concentrations of 50-100 mg/kg may boost antioxidant defense and demonstrate hepatoprotective property while higher concentrations may be pro-oxidative.

Full Text: PDF

Refbacks

  • There are currently no refbacks.