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This study was carried out to determine the antibacterial activities of seed and pod extracts of Prosopis africana at
25mg/ml concentration against fifteen bacterial isolates namely: Klebsiella pneumoniae, Bacillus anthracis,
Bacillus subtilis, Bacillus stearothermophilus, Bacillus polymyxa, Methilin-resistant Staphylococcus aureus
(MRSA), Proteus vulgaris, Cornybacterium pyogenes, Micrococcus leutus, Pseudomonas aeruginosa, Bacillus
cereus, Staphyloococcus aureaus, Pseudomonas fluorescence, Streptococcus fecalis and Escherichia coli. The
results obtained showed that all the isolates appeared to be susceptible to Ciprofloxacin (control) with the zone of
inhibition ranging from 25mm-50mm. The pod extract was susceptible to K. pneumoniae, B. anthracis, B.
stearothermophilus, B. polymyxa, Clostridium pyogenes, Pseudomonas aeruginosa, B. cereus, Staphyloococcus
aureaus, P. fluorescence, Streptoococcus fecalis, E. coli were having zones of inhibition to be between 8mm-17mm
in diameter. For the seed extract, K. pneumoniae, B. polymyxa, E. coli, S. aureaus, S. fecalis, P. aeruginosa, B.
subtilis were susceptible with the zones of inhibition ranging between 5mm-14mm. The minimum inhibitory
concentration (MIC) analysed on the seed extract showed at least 1.562% in the bacterial strains tested. The
phytochemical analysis of the seed extract revealed that saponin, alkaloids, steroids, flavonoids, phlabotanin and
tannin were present in the extracts of seed and pod. However cardiac glucosides was absent in the seed extract. The
proximate composition consists of moisture content (3.3±0.0%), total ash (4.4±0.1%), crude protein (23.6±1.5%),
crude fibre (54±0.8%) and carbohydrate (1.9±0.3%). The predominant mineral found in the seed were Potassium,
(K) (617.5mg/100g sample), Magnesium (Mg) (420.1mg/100g sample). Others were Sodium (Na), Calcium,
Phosphorus, Manganese (Mn), Copper (Cu), Zinc (Zn), and iron ( Fe) were 110.7, 362.5, 196.4, 36.2, 46.2, 22.4 and
15.5mg/100g sample respectively. This study indicates the potential efficacy of Prosopis africana in the treatment of
various infections caused by the test organisms.
Keyword: Prosopis africana, Phytochemical screening and Seed