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The proximate analysis for Cucumeropsis mannii (Naud.) and Citrullus lanatus (var. citroides) seeds was carried out to determine their potential as efficient oil sources.  Cucumeropsis mannii (Naud.) and Citrullus lanatus (var. citroides) oils were obtained using n-hexane (25oC). The physicochemical properties of the oil extract including the refractive index, specific gravity, acid value, free fatty acid content, saponification value, unsaponifiable matter content, peroxide value, and the iodine value. The resulting values were compared with international standards for edible oils. Proximate analysis of Cucumeropsis mannii (Naud.) and Citrullus lanatus (var. citroides) seeds showed a total fat content of 48.30% and 52.2% respectively. The polyunsaturated fatty acids content of Cucumeropsis mannii (Naud.) and Citrullus lanatus (var. citroides), demonstrated by the high saponification values (161.29 and 189.34 respectively) and iodine values (77.4 Wij’s and 80.64 Wij’s respectively) indicate good health potential as cooking oils while the low peroxide (0.60mg/kg and 0.45mg/kg respectively) and acid values (1.26mgKOH/g and 0.98mgKOH/g respectively) of the oils demonstrate the resistance of these oils to rancidity. The proximate analysis of the seeds and physicochemical properties of the extracted oils placed C.lanatus (var. citroides) in a brighter position of potential as a cooking oil source with a higher total fat content of 52.20% compared to C. mannii (Naud.)’s 48.30%. Keywords: Seed oils, Melon seeds, C. mannii (Naud.), C.lanatus (var. citroides), Physicochemical analysis.