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Malaria remains the leading cause of mortality among parasitic infectious diseases worldwide, especially in the tropical and Sub-tropical regions of the world. The current study evaluated the prevalence of malaria infection in Ifedore Local Government Area of Ondo State, Nigeria. A total of 2,063 patients attending selected hospitals and health centres across eleven major settlements in the Local Government Area were enrolled for the study. Blood samples were obtained from the patients and examined for malaria parasite(s) using thick blood film microscopy. Demographic information of each patient was obtained using well structured closeended questionnaire while data obtained were analyzed to test for significance using Pearson’s Chi-Square at P=0.05. Results revealed a total of 1,619 (78.5%) participants positive for malaria infection. Respondents from Aaye town recorded the highest prevalence of infection at 95.1% while the least prevalence of 52.5% was recorded from Ero town. There was a significant difference (P<0.05) in the prevalence of infection among the sexes with the male (81.0%) having a higher prevalence than the female (76.8%). There was high prevalence of malaria infection across the study area which calls for more investigation into, and recommendation of, laudable control and preventive programmes. Keywords: Prevalence, Malaria, Plasmodium, Ifedore LGA, Control.