The present work aimed to determine the effect of different doses of ionizing radiation
of x-rays on the level of some redox-active metabolites and gross antioxidant status in rats’ testicular
tissues that were previously exposed to different doses of ionizing radiation. Rats were exposed to
different doses of x-rays ionizing radiation for 20 seconds/day for a period of 9 days. The level of
reduced glutathione (GSH), vitamin C and level of malondialdehyde (MDA) were determined. In
addition, the free radical scavenging property as well as the ability of the whole testicular tissue to
reduce and chelate the redox-active transition metal iron was used as indices of the gross antioxidant
status of the rats’ testes. The results showed that while the ionizing radiation evoked a dosedependent
diminution on the level of GSH and vitamin C, it caused an increase in the level of MDA,
an index of oxidative assault on cellular lipids. In addition, the ionizing radiation reduced the ability
of the whole testicular tissue to scavenge radicals, reduced Fe3+ and chelate Fe2+. Consequently, it
appears that while the ionizing radiation diminished the level of antioxidant biomolecules, it also
exerted deleterious redox pressure on the gross antioxidant defense system of the testicular tissues.
PAPER TITLE :IONIZING RADIATION EVOKES DISTURBED REDOX-ACTIVE METABOLITE HOMEOSTASIS AND ANTIOXIDANT STATUS IN RAT TESTICULAR TISSUE
JOURNAL Of SUSTAINABLE TECHNOLOGY | VOLUME 8 NUMBER 2 2017
Paper Details
- Author(s) : FAROMIKA, O.P. KADE, I.J. and FATUKASI, J.O.
- Abstract:
