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The study sought to evaluate the effects of phenolic extract from bush buck (Gongronema latifolium) and wonder kola (buchholzia coriacea) on key enzymes linked to neurodegeneration (acetylcholinesterase, butyrylcholinesterase and monoamine oxidase (MAO)). Ten grams each of thewonder kola and bush buck was soaked in 200 ml of mixture of methanol and 1N HCl (1:1 v/v) for 24 hours and filtered. The filtrate was evaporated at 45oC to dryness and reconstituted in distilled water for subsequent assays such as cholinetsrase, monoamine oxidase and antioxidant assays. The results revealed that the phenolic extracts inhibited acetylcholinesterase, butyrycholinesterase and monoamine oxidase in a concentration-dependent manner (0 – 800 µg/ml). However, wonder kola [acetylcholinesterase (EC50= 453.31 µg/ml), butyrylcholinesterase (EC50= 453.72 µg/ml), monoamine oxidae (EC50=954.20 µg/ml)] had significant (P< 0.05) higher inhibitory effects than bush buck kola [acetylcholinesterase (EC50=1182.94 µg/ml), butyrylcholinesterase (EC50=591.72 µg/ml), monoamide oxidae (EC50=1041.67µg/ml]. Furthermore, incubation of brain tissue homogenate with 250µM FeSO4 caused significant (p<0.05) increase in the malondialdehyde (MDA) content of the brain tissue homogenate compared to the basal. However, bush buck (IC50= 805.24 µg/ml) had significant (p<0.05) higher MDA inhibitory effect than wonder kola (IC50 =1182.94 µg/ml). Also, wonder kola [FRAP=117.53mgAAE, DPPH• (EC50= 337.61), Fe2+ chelation (EC= 118.5µg/ml)] had significantly (p<0.05) higher antioxidant properties than bush buck [FRAP=100 mgAAE, DPPH• (EC50= 401.61 µg/ml), Fe2+ chelation (EC= 171.9µg/ml]. We therefore conclude that inhibition of acetylcholinesterase, butyrlcholinesterase and monoamine oxidase enzymatic activities coupled with strong antioxidant properties of bush buck (Gongronema latifolium) and wonder kola (buchholzia coriacea) could underlie their importance in neuroprotection, though, wonder kola (buchholzia coriacea) showed promising potential than bush buck (Gongronema latifolium) Keywords: wonderful kola, bush buck, acetylcholinesterase, butyrlcholinesterase, monoamine oxidase, antioxidant