Eggplants have been considered a natural therapy for the management of type-2 diabetes, but little is known about biological activities of Solanum aethiopicum and Solanum incanum in the management of type-2 diabetes. Hence, this study investigated the antioxidant activities and inhibitory actions of S. aethiopicum and S. incanum on starch-metabolizing enzymes. In addition, the effect of S. aethiopicum and S. incanum extracts on Fe2+-induced oxidative stress in pancreas was examined. Results from this study reveal that extracts of S. aethiopicum and S. incanum have good antioxidant activities and mild α-amylase and strong α-glucosidase inhibitory activity. Inhibition of these enzymes coupled with antioxidant activities of S. aethiopicum and S. incanum suggest the possible biochemical basis for their involvement in the management of type-2 diabetes. However, consumption of S. aethiopicum and S. incanum could be considered a dietary therapy with potential of controlling glucose absorption and hyperglycemia linked to oxidative stress.
Keywords: S. aethiopicum; S. incanum; oxidative stress; type-2 diabetes.
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