PAPER TITLE :EVALUATION OF THE ANTI-ULCEROGENIC PROPERTIES OF ETHANOLIC EXTRACT OF PTEROCARPUS ERINACEUS AND HOMOPTEROCARPIN AGAINST ASPIRIN-INDUCED ULCER IN ALBINO RATS

FUTA JOURNAL OF RESEARCH IN SCIENCE | VOLUME 9 NUMBER 1 2013

Paper Details

  • Author(s) : 1M.T. Olaleye, 1C.T. Ojo and 2A.O. Adetuyi
  • Abstract:

Pterocarpus erinaceus is a medicinal plant with many therapeutic properties. This study
evaluated anti-ulcerogenic activity of stem bark extract of P. erinaceus and homopterocarpin against aspirininduced
gastric mucosal injury in albino rats. The albino rats were divided into five groups. Group I received
olive oil, groups III-V were pre-treated with 100mg/kg cimetidine, 25mg/kg homopterocarpin and 100mg/kg
test extract forty-five minutes before ulcer induction. The stomachs of the sacrificed animals were evaluated
for ulcer indices, pH, volume and acid concentration of the gastric juice, mucus concentration,
malondialdehyde level, reduced glutathione level, superoxide dismutase activity and total protein. Aspirin
produced significant alterations in ulcer index, mucus concentration, and gastric juice parameters, compared
to the control. The results show that test extract and homopterocarpin were able to exert protective effects
against aspirin induced gastric ulcers in albino rats. The protective effects might be via anti-secretory,
cytoprotective and antioxidative mechanisms.
Keywords: P. erinaceus; antioxidative; ulcer; aspirin